Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ®) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.
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Hypothyroidism, thyroid dysfunction e. Fertility It is not known whether octreotide has an effect on human fertility.
Skin and subcutaneous tissue disorders Urticaria.
The most frequent adverse reactions reported during octreotide therapy include gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders. Last updated on eMC: All the information available at present indicates that the findings in rats are specific and have no significance for the use of the drug in humans see section 5.
Diarrhoea, abdominal pain, nausea, constipation, flatulence. Sign Up Log In Cancel. Successful preparation and administration of Sandostatin LAR Depot relies on proper adherence to the steps below. Octreotide is a synthetic octapeptide derivative of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolonged duration of action.
Beginning with this low dose may permit adaptation to adverse gastrointestinal effects for patients who will require higher doses.
Hypersensitivity and doais reactions have been octreotidf during post-marketing experience. The elimination capacity may be reduced in patients with liver cirrhosis, but not in patients with fatty liver disease.
Adverse drug reactions Table 1 are ranked under heading of frequency, the most frequent first, using the following convention: Proper sterile technique should be used in the preparation of parenteral admixtures to minimize the possibility of microbial contamination. Each 1 ml of solution for injection contains micrograms of Octreotide as octreotide acetate. In many cases, this is accompanied by a fall in plasma serotonin and reduced urinary excretion of 5-hydroxyindole acetic acid.
Packs of 5 and 30 vials containing 1 ml of solution for injection. The amount of Sandostatin bound to blood cells ocrreotide negligible. Sandostatin LAR Depot is available in 10 mg, 20 mg, and 30 mg for ocrreotide or down dose titration. Administration of Sandostatin produces a fall in circulating immunoreactive insulin, which may, however, be of short duration about 2 hours. Schedule an in-office demonstration on mixing and administration.
Dosing Sandostatin® LAR®
Nutrition Octreotide may alter absorption of dietary fats in some patients. Package of 10 ampuls……………………………………………………. Use in children Experience with Sandostatin in children is limited. Not compatible with TPN solutions.
Sandostatin 50 microgram/1 ml, solution for injection/infusion
Elimination The elimination half-life after s. Acute pancreatitis, acute hepatitis without cholestasis, cholestatic hepatitis, cholestasis, jaundice, cholestatic jaundice. Octreotide has no or negligible influence on the ability to drive and use machines. Sandostatin’s effects in the different tumour types are as follows Carcinoid tumours Administration of Sandostatin may result octrotide improvement of symptoms, particularly of flushing and diarrhoea.
Insulin requirements of patients with type I diabetes mellitus therapy may be reduced by administration of Octreotide. In addition, cholelithiasis induced pancreatitis has been reported for ochreotide on long-term Octreotide s.
Marketing authorisation holder 8. Upward dose titration is frequently required. Continue typing to refine.
The frequency of gastrointestinal adverse events is known to decrease over time with continued treatment. This medicinal product must not be mixed with other medicinal products, except those mentioned in section 6.
In most cases, administration of octreotide results in alleviation of the severe secretory diarrhoea typical of the condition, with consequent improvement in quality of life.
As a precautionary measure, it is preferable to avoid the use of Sandostatin during pregnancy see section 4. Repeat moderate shaking for another 30 seconds if the powder is not completely suspended.
Late descent of the testes was found for male offspring of dam treated during pregnancy and lactation.